Serum bisphenol-A concentration and sex hormone levels in men.
Zhou Q; Miao M; Ran M; Ding L; Bai L; Wu T; Yuan W; Gao E; Wang J; Li G; Li D-K
Fertil Steril 2013 Aug; 100(2):478-482
OBJECTIVE: To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 290 men with or without BPA exposure in the workplace. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Serum sex hormone levels. RESULT(S): After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with  decreased androstenedione levels,  decreased free testosterone levels,  decreased free androgen index, and  increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations. CONCLUSION(S): Exposure to a high BPA level may impact sex hormone levels in men.
Humans; Men; Age-groups; Hormones; Sex-factors; Exposure-levels; Biphenyls; Blood-analysis; Blood-cells;
Author Keywords: Bisphenol-A; BPAl endocrine disruption; men; sex hormones
Jintao Wang, M.D., Ph.D., Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, People's Republic of China
Fertility and Sterility
Kaiser Foundation Research Institute