NIOSHTIC-2 Publications Search

Simple, distance-based measurement for paper analytical devices.

Cate DM; Dungchai W; Cunningham JC; Volckens J; Henry CS

Lab Chip 2013 Jun; 13(12):2397-2404

https://doi.org/10.1039/c3lc50072a

20043529

Paper-based analytical devices (PADs) represent a growing class of elegant, yet inexpensive chemical sensor technologies designed for point-of-use applications. Most PADs, however, still utilize some form of instrumentation such as a camera for quantitative detection. We describe here a simple technique to render PAD measurements more quantitative and straightforward using the distance of colour development as a detection motif. The so-called distance-based detection enables PAD chemistries that are more portable and less resource intensive compared to classical approaches that rely on the use of peripheral equipment for quantitative measurement. We demonstrate the utility and broad applicability of this technique with measurements of glucose, nickel, and glutathione using three different detection chemistries: enzymatic reactions, metal complexation, and nanoparticle aggregation, respectively. The results show excellent quantitative agreement with certified standards in complex sample matrices. This work provides the first demonstration of distance-based PAD detection with broad application as a class of new, inexpensive sensor technologies designed for point-of-use applications.

Analytical-instruments; Blood-analysis; Nickel-compounds; Nanotechnology; Enzymatic-effects; Analytical-processes; Metabolism; Oximes; Peroxidases; Metal-compounds; Metallic-compounds

Charles S. Henry, Department of Chemistry, Colorado State University, Fort Collins, CO 80523

LCAHAM

7440-02-0

20130621

Journal Article

chuck.henry@colostate.edu

Grant

2013

Grant-Number-R21-OH-010050; M122013

12

1473-0197

Lab on a Chip

CO

Colorado State University - Fort Collins