ROS evaluation for series of CNTs using the ESR method and the effects of CNT morphology.
Tsuruoka-S; Takeuchi-K; Koyama-K; Fujisawa-K; Matsumoto-H; Saito-N; Usui-Y; Porter-DW; Castranova-V; Endo-M
Nanotech Conference and Expo 2013: Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, May 12-16, 2013, Washtington, DC. Volume 3: Bio Sensors, Instruments, Medical, Environment and Energy. Boca Raton, FL: CRC Press, 2013 Jun; 3:449-452
Carbon nanotubes (CNTs) are becoming important materials in industry. It is a concern that CNTs may induce carcinogenic responses through pulmonary exposure. It has been recently reported that CNTs scavenge radical oxygen species (ROS) depending on their morphology. ROS production has been utilized for toxicological evaluations. The present work specifically investigates ROS scavenging capabilities using the series of CNTs and their derivatives with surface modifications. Those ROS scavenging properties were measured by ESR with 5, 5-Dimethyl-1-pyrroline N-oxide (DMPO). Highly crystallized, mechanically chopped, and mechanically de-bulked CNTs were evaluated. Furthermore, their surface modification by nitric acid and ozone was compared with untreated CNTs.
Nanotechnology; Carbonyls; Carbonates; Carcinogens; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-function; Respiratory-system-disorders; Respiration; Exposure-levels; Risk-factors; Toxicology;
Author Keywords: ROS; morphology; CNTs; ESR
Nanotech Conference and Expo 2013: Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, May 12-16, 2013, Washtington, DC. Volume 3: Bio Sensors, Instruments, Medical, Environment and Energy