Nitrosothiol signaling in anoikis resistance and cancer metastasis.
Luanpitpong-S; Iyer-AKV; Azad-N; Wang-L; Rojanasakul-Y
For Immunopathol Dis Therap 2012 Apr-Jun; 3(2):141-154
Nitric oxide (NO) has been widely recognized as an important cell-signaling molecule that regulates various physiological and pathological processes. S-nitrosylation, or covalent attachment of NO to protein sulfhydryl groups, is a key mechanism by which NO regulates protein functions and cellular processes. In this article we discuss the various roles of NO and protein nitrosylation in cancer development, with a focus on cell invasion and anoikis resistance, both of which are key determinants of cancer metastasis. We specially address some of the mechanisms by which NO-mediated S-nitrosylation modulates substrates that have putative effects on key steps of metastasis. We propose that nitrosothiol signaling is a key regulatory mechanism common to several pathways involved in cancer progression and metastasis, and identifying such a mechanism will improve our understanding of the disease process and aid in the development of novel anticancer therapeutics.
Cellular-function; Nitroso-compounds; Oxides; Molecular-biology; Proteins; Sulfhydryls; Cancer; Cellular-reactions; Disease-prevention; Physiological-response; Pathology; Biological-effects; Cell-damage; Cell-morphology;
Author Keywords: nitric oxide; S-nitrosylation; cancer; metastasis; anoikis; invasion
Yon Rojanasakul, PhD, West Virginia University, Health Sciences Center, P.O. Box 9530, Morgantown, WV 26506
Forum on Immunopathological Diseases and Therapeutics