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Biomonitoring of polycyclic aromatic hydrocarbons from coke oven emissions and reproductive toxicity in nonsmoking workers.

Jeng HA; Pan C-H; Lin W-Y; Wu M-T; Taylor S; Chang-Chien G-P; Zhou G; Diawara N

J Hazard Mater 2013 Jan; 244-245:436-443

https://doi.org/10.1016/j.jhazmat.2012.11.008

20042846

The objective of the cross-sectional study was to assess whether exposure to polycyclic aromatic hydrocarbons (PAHs) from coke oven emissions contributed to alteration of semen quality and sperm DNA integrity in nonsmoking workers. Nonsmoking coke oven workers from a steel plant in Taiwan served as the exposure groups (topside-oven workers for the high exposure group and side-oven workers for the low exposure group), and administrators and security personnel in the plant served as the control. An exposure assessment was conducted to determine both particulate and gaseous phase of PAH levels and urinary 1-hydroxypyrene (1-OHP) levels. Semen quality was analyzed according to WHO guidelines. DNA fragmentation and bulky DNA adducts were measured to assess sperm DNA integrity. There was no significant difference in sperm concentrations, vitality, and DNA fragmentation between the exposed group and the control. The high exposure group experienced significantly lower percentages of normal morphology as compared with the control (p=0.0001). Bulky DNA adducts were detected in the exposed group that were significant higher than the control (p=0.04). Exposure to PAHs from coke-oven emissions could contribute to increased levels of bulky DNA adducts in sperm.

Reproductive-system-disorders; Reproductive-effects; Polycyclic-aromatic-hydrocarbons; Coke-ovens; Coke-oven-emissions; Coke-oven-workers; Biological-effects; Biological-monitoring; Humans; Men; Sex-factors; DNA-damage; Worker-health; Employee-exposure; Hydroxy-compounds; Pyrenes; Steel-foundries; Steelworkers; Exposure-assessment; Urinalysis; Particulates; Gases; Cell-alteration; Cell-morphology; DNA-adducts; Morphology; Toxic-materials; Spermatozoa; Air-contamination; Work-environment; Author Keywords: Polycyclic aromatic hydrocarbons; Semen quality; Morphology; Vitality; 1-Hydroxypyrene; DNA fragmentation

Hueiwang Anna Jeng, School of Community and Environmental Health, Old Dominion University, 4608 Hampton Boulevard, Health Sciences Building, Room 3140, Norfolk, VA, USA

JHMAD9

5315-79-7

20130115

Journal Article

hjeng@odu.edu

Grant

2013

Grant-Number-R03-OH-009504; B20130801

0304-3894

Journal of Hazardous Materials

VA; TX

Old Dominion University, Norfolk, Virginia