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Long-term efficacy of a program to prevent beryllium disease.
Thomas-CA; Deubner-DC; Stanton-ML; Kreiss-K; Schuler-CR
Am J Ind Med 2013 Jul; 56(7):733-741
BACKGROUND: In 2000, a manufacturer of beryllium materials and products introduced a comprehensive program to prevent beryllium sensitization and chronic beryllium disease (CBD). We assessed the program's efficacy in preventing sensitization 9 years after implementation. METHODS: Current and former workers hired since program implementation completed questionnaires and provided blood samples for the beryllium lymphocyte proliferation test (BeLPT). Using these data, as well as company medical surveillance data, we estimated beryllium sensitization prevalence. RESULTS: Cross-sectional prevalence of sensitization was 0.7% (2/298). Combining survey results with surveillance results, a total of seven were identified as sensitized (2.3%). Early Program workers were more likely to be sensitized than Late Program workers; one of the latter was newly identified. All sensitization was identified while participants were employed. One worker was diagnosed with CBD during employment. CONCLUSIONS: The combination of increased respiratory and dermal protection, enclosure and improved ventilation of high-risk processes, dust migration control, improved housekeeping, and worker and management education showed utility in reducing sensitization in the program's first 9 years. The low rate (0.6%, 1/175) among Late Program workers suggests that continuing refinements have provided additional protection against sensitization compared to the program's early years.
Beryllium-compounds; Beryllium-disease; Workers; Questionnaires; Blood-samples; Surveillance-programs; Sensitization; Humans; Men; Women; Exposure-levels; Respiratory-protection; Skin; Skin-protection; Ventilation; Dust-control; Education; Author Keywords: beryllium; hypersensitivity; safety management; occupational exposure; program evaluation
Christine R. Schuler, PhD, Division of Respiratory Disease Studies, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Field Studies Branch,1095Willowdale Road,MS 2800,Morgantown,WV 26505
Issue of Publication
American Journal of Industrial Medicine
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division