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Pulmonary function predicting confirmed recovery from lower-respiratory symptoms in World Trade Center-exposed firefighters, 2001 to 2010.
Soo J; Webber MP; Hall CB; Cohen HW; Schwartz TM; Kelly KJ; Prezant DJ
Chest 2012 Nov; 142(5):1244-1250
BACKGROUND: We examined the relationship between pulmonary function (FEV 1) and confirmed recovery from three lower-respiratory symptoms (LRSs) (cough, dyspnea, and wheeze) up to 9 years after symptom onset. METHODS: The study included white and black male World Trade Center (WTC)-exposed firefighters who reported at least one LRS on a medical monitoring examination during the first year after September 11, 2001. Confirmed recovery was defined as reporting no LRSs on two consecutive and all subsequent examinations. FEV 1 was assessed at the first post-September 11, 2001, examination and at each examination where symptom information was ascertained. We used stratified Cox regression models to analyze FEV 1, WTC exposure, and other variables in relation to confirmed symptom recovery. RESULTS: A total of 4,368 firefighters met inclusion criteria and were symptomatic at year 1, of whom 1,592 (36.4%) experienced confirmed recovery. In univariable models, first post-September 11,2001, concurrent, and difference between first post-September 11, 2001, and concurrent FEV 1 values were all significantly associated with confirmed recovery. In adjusted analyses, both first post-September 11, 2001, FEV 1 (hazard ratio [HR], 1.07 per 355-mL difference; 95% CI, 1.04-1.10) and FEV 1 % predicted (HR, 1.08 per 10% predicted difference; 95% CI, 1.04-1.12) predicted confirmed recovery. WTC exposure had an inverse association with confirmed recovery in the model with FEV 1, with the earliest arrival group less likely to recover than the latest arrival group (HR, 0.73;95% CI, 0.58-0.92). CONCLUSIONS: Higher FEV 1 and improvement in FEV 1 after September 11, 2001, predicted confirmed LRS recovery, supporting a physiologic basis for recovery and highlighting consideration of spirometry as part of any postexposure respiratory health assessment.
Pulmonary-function; Pulmonary-function-tests; Respiratory-function-tests; Sound; Lung-function; Lung-irritants; Etiology; Physiopathology; Emergency-responders; Rescue-workers; Fire-fighters; Humans; Men; Lung-disease; Medical-monitoring; Medical-examinations; Spirometry; Environmental-exposure; Employee-exposure; Exposure-assessment
Mayris P. Webber, DrPH, MPH, New York City Fire Department, Bureau of Health Services, 9 Metrotech Center, Brooklyn, NY 11201
Grant; Cooperative Agreement
Grant-Number-R01-OH-007350; Cooperative-Agreement-Number-U10-OH-008243; Cooperative-Agreement-Number-U10-OH-008242
Issue of Publication
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division