Lung disease in Chinese textile workers.
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2010 Apr; :1-8
The proposed study is a competing continuation of R01 OH 02421. This proposal is designed to address unanswered questions regarding the respiratory health of workers chronically exposed to organic dust (specifically cotton dust) and endotoxin. Exposure to gram-negative bacterial endotoxin has been described in laboratory studies as producing acute respiratory symptoms and lung function change. Similar observations have not been reproduced in actual mill settings. To date, no other prospective epidemiologic study has addressed the relative contributions of cotton dust and endotoxin in producing both acute and chronic respiratory effects. In addition, we will examine the long-term effects of removal by retirement from exposure on respiratory health status. This is possible because of documented accessibility to workers who have left the workforce. The importance of endotoxin in causing pulmonary effects is important not only in the cotton textile industry, but also in a number multitude of other environments where significant levels of airborne endotoxin are encountered. The study population (closed cohort) that has been followed since 1981 and is unusually well-suited for epidemiologic study due to: low turnover, very low smoking prevalence among women workers, reliable baseline data, a suitable comparison group studied in identical fashion, excellent cooperation among industry officials, union and the collaborative research team, access to subjects who have retired or left the industry in disability, and cost-efficiency. The population included 447 cotton textile and 465 silk textile workers first surveyed in 1981. Follow-up surveys were conducted in 1986, 1992, and 1996, 2001 and 2006 with excellent follow-up. The proposed study is unique because exposure estimates for both dust and endotoxin over a 25-year period allowed assessment of exposure-response relationships for both dust and endotoxin for the full study interval.
Pulmonary-system-disorders; Textiles-industry; Cotton-dust; Cotton-mill-workers; Plant-dusts; Dust-exposure; Pulmonary-function; Occupational-exposure; Endotoxins; Exposure-levels; Bacteria; Bacterial-dusts; Respirable-dust; Respiration; Respiratory-system-disorders; Pulmonary-function; Pulmonary-system; Lung; Lung-disorders; Lung-function; Lung-irritants; Milling-industry; Cotton-industry; Cotton-mill-workers; Cotton-dust; Organic-dusts; Organic-compounds; Epidemiology; Airborne-dusts; Humans; Men; Women; Statistical-analysis
Dr. David C. Christiani, MD, MPH, Harvard School of Public Health, 665 Huntington Avenue, Room 1-1401, Boston, MA 02115
Final Grant Report
NTIS Accession No.
National Institute for Occupational Safety and Health