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Changes in E-cadherin in the cochlea after traumatic noise exposure.
Tanaka C; Chen G-D; Hu BH; Salvi R; Henderson D
Abstr Midwinter Res Meet Assoc Res Otolaryngol 2009 Feb; 32:47
Leonova and Raphael (1997) reported that the adhesion molecule, E-cadherin, alters distribution patterns resulting from scar tissue formation in the cochlea after administration of kanamycin. They speculated that E-cadherin may play an important role in the transmission of sound and the process of the scar tissue formation in the cochlea after ototoxic drug administration. We investigated changes in E-cadherin in the organ of Corti in rats immediately after exposure to a traumatic noise (10- 20 kHz broad band noise at 110 dB SPL for 4 hours) using a confocal microscope. Similar to the previous study (Leonova and Raphael, 1997), E-cadherin was found in the reticular lamina. However, intense E-cadherin staining that outlined the apical part of the outer hair cells (OHCs) was observed in the reticular lamina in the noise-induced damage lesion (basal turn) immediately after the noise exposure. This phenomenon was not observed in the unexposed control animals. The OHCs that showed localization of E-cadherin, were found to be apoptotic or have missing nuclei. This E-cadherin localization may be related to the mechanical stress caused by the intense noise since this phenomenon was not previously observed in the kanamycin-treated cochlea. This study was supported by NIOSH grant 1R01OH008113-01A1.
Noise-exposure; Exposure-levels; Noise-induced-hearing-loss; Noise-exposure; Noise; Hearing; Hearing-disorders; Hearing-loss; Laboratory-animals; Animals; Molecular-structure; Tissue-culture
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Abstracts of the 32nd Midwinter Research Meeting of the Association for Research in Otolaryngology, Febuary 14-19, 2009, Baltimore, Maryland
MO; MD; NY
Washington University, St. Louis
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