Longitudinal spirometry among patients in a treatment program for community members with World Trade Center-related illness.
Liu-M; Qian-M; Cheng-Q; Berger-KI; Shao-Y; Turetz-M; Kazeros-A; Parsia-S; Goldring-RM; Caplan-Shaw-C; Fernandez-Beros-ME; Marmor-M; Reibman-J
J Occup Environ Med 2012 Oct; 54(10):1208-1213
OBJECTIVE: The course of lung function in community members exposed to World Trade Center (WTC) dust and fumes remains undefined. We studied longitudinal spirometry among patients in the WTC Environmental Health Center (WTCEHC) treatment program. METHODS: Observational study of 946 WTCEHC patients with repeated spirometry measures analyzed on the population as a whole and stratified by smoking status, initial spirometry pattern, and WTC-related exposure category. RESULTS: Improvement in forced vital capacity (54.4 mL/yr; 95% confidence interval, 45.0 to 63.8) and forced expiratory volume in 1 second (36.8 mL/yr; 95% confidence interval, 29.3 to 44.3) was noted for the population as a whole. Heavy smokers did not improve. Spirometry changes differed depending on initial spirometry pattern and exposure category. CONCLUSION: These data demonstrate spirometry improvement in select populations suggesting reversibility in airway injury and reinforcing the importance of continued treatment.
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Rescue-workers; Hazardous-materials; Dust-exposure; Dust-particles; Dusts; Dose-response; Lung-function; Spirometry; Respiratory-function-tests; Smoking; Cigarette-smoking; Medical-monitoring; Medical-treatment; Medical-screening; Airway-obstruction
Joan Reibman, MD, 550 1st Ave, Room NB7N24, New York University School of Medicine, New York, NY 10016
Grant-Number-E11-OH-009630; Contract-200-2011-39391; Contract-200-2011-39413; Contract-200-2011-39379; B10152012
Journal of Occupational and Environmental Medicine
New York City Health and Hospitals Corporation