Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.
Shvedova-AA; Tkach-AV; Kisin-ER; Khaliullin-T; Stanley-S; Gutkin-DW; Star-A; Chen-Y; Shurin-GV; Kagan-VE; Shurin-MR
Small 2013 May; 9(9-10):1691-1695
Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
Nanotechnology; Lung; Lung-disease; Lung-disorders; Lung-cancer; Cancer; Carcinomas; Cell-function; Cellular-function; Cell-biology; Microbiology; Surveillance-programs; Immune-reaction; Immune-system;
Author Keywords: Lewis lung carcinoma; myeloid-derived suppressor cells; SWCNT; tumor metastasis
Anna A. Shvedova, Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
University of Pittsburgh at Pittsburgh