Krajnak-K; Miller-GR; Waugh-S; Johnson-C; Kashon-ML
J Occup Environ Med 2012 Aug; 54(8):1010-1016
Objective: Occupational exposure to hand-transmitted vibration can result in damage to nerves and sensory loss. The goal of this study was to assess the frequency-dependent effects of repeated bouts of vibration on sensory nerve function and associated changes in nerves. Methods: The tails of rats were exposed to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s(2)) for 10 days. The effects on sensory nerve function, nerve morphology, and transcript expression in ventral tail nerves were measured. Results: Vibration at all frequencies had effects on nerve function and physiology. However, the effects tended to be more prominent with exposure at 250 Hz. Conclusion: Exposure to vibration has detrimental effects on sensory nerve function and physiology. However, many of these changes are more prominent at 250-Hz exposure than at lower frequencies.
Vibration; Vibration-disease; Vibration-effects; Vibration-exposure; Injury-prevention; Animal-studies; Laboratory-animals; Exposure-assessment; Exposure-levels; Nerve-function; Neurological-reactions; Nerve-damage; Sensory-disorders; Hand-tools; Hand-injuries; Neurophysiological-effects; Physiological-effects; Repetitive-work
Kristine Krajnak, PhD, Biostatics and Epidemiology Branch, NIOSH, 1095 Willowdale Road, MS2027, Morgantown, WV 26505
Journal of Occupational and Environmental Medicine