NIOSHTIC-2 Publications Search
Frequency-dependent effects of vibration on peripheral nerves and sensory nerve function in a rat model of hand-arm vibration syndrome.
Krajnak K; Miller GR; Waugh S; Johnson C; Kashon ML
J Occup Environ Med 2012 Aug; 54(8):1010-1016
Objective: Occupational exposure to hand-transmitted vibration can result in damage to nerves and sensory loss. The goal of this study was to assess the frequency-dependent effects of repeated bouts of vibration on sensory nerve function and associated changes in nerves. Methods: The tails of rats were exposed to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s(2)) for 10 days. The effects on sensory nerve function, nerve morphology, and transcript expression in ventral tail nerves were measured. Results: Vibration at all frequencies had effects on nerve function and physiology. However, the effects tended to be more prominent with exposure at 250 Hz. Conclusion: Exposure to vibration has detrimental effects on sensory nerve function and physiology. However, many of these changes are more prominent at 250-Hz exposure than at lower frequencies. (<a href="http://dx.doi.org/10.1097/JOM.0b013e318270d560"target="_blank"a>Erratum: Characterization of frequency-dependent responses of the vascular system...</a>.
Vibration; Vibration-disease; Vibration-effects; Vibration-exposure; Injury-prevention; Animal-studies; Laboratory-animals; Exposure-assessment; Exposure-levels; Nerve-function; Neurological-reactions; Nerve-damage; Sensory-disorders; Hand-tools; Hand-injuries; Neurophysiological-effects; Physiological-effects; Repetitive-work
Kristine Krajnak, PhD, Biostatics and Epidemiology Branch, NIOSH, 1095 Willowdale Road, MS2027, Morgantown, WV 26505
Issue of Publication
Journal of Occupational and Environmental Medicine
Page last reviewed: October 8, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division