Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.
Tkach-AV; Yanamala-N; Stanley-S; Shurin-MR; Shurin-GV; Kisin-ER; Murray-AR; Pareso-S; Khaliullin-T; Kotchey-GP; Castranova-V; Mathur-S; Fadeel-B; Star-A; Kagan-VE; Shvedova-AA
Small 2013 May; 9(9-10):1686-1690
Graphene oxide (GO) and C(60) - or C(60) -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells.T-cells in different ways. While C(60) -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C(60) -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.
Oxides; Cell-alteration; Cell-function; Cellular-reactions; Antigens; Dose-response; Proteins; Vaccines; Cytology; Immune-reaction; Immune-system; Immune-system-disorders;
Author Keywords: antigens; dendritic cells; fullerenes; graphene oxide; immune suppression
Anna A. Shvedova, Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown WV 26505, USA
University of Pittsburgh at Pittsburgh