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Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.
Authors
Tkach AV; Yanamala N; Stanley S; Shurin MR; Shurin GV; Kisin ER; Murray AR; Pareso S; Khaliullin T; Kotchey GP; Castranova V; Mathur S; Fadeel B; Star A; Kagan VE; Shvedova AA
Source
Small 2013 May; 9(9-10):1686-1690
NIOSHTIC No.
20041340
Abstract
Graphene oxide (GO) and C(60) - or C(60) -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells.T-cells in different ways. While C(60) -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C(60) -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.
Keywords
Oxides; Cell-alteration; Cell-function; Cellular-reactions; Antigens; Dose-response; Proteins; Vaccines; Cytology; Immune-reaction; Immune-system; Immune-system-disorders;
Author Keywords: antigens; dendritic cells; fullerenes; graphene oxide; immune suppression
Contact
Anna A. Shvedova, Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown WV 26505, USA
CODEN
SMALBC
Publication Date
20130527
Document Type
Journal Article
Email Address
ats1@cdc.gov
Funding Type
Grant
Fiscal Year
2013
Identifying No.
Grant-Number-R01-OH-008282; B08292012
Issue of Publication
9-10
ISSN
1613-6810
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Small
State
PA; WV
Performing Organization
University of Pittsburgh at Pittsburgh
Page last reviewed: May 11, 2023
Content source:
National Institute for Occupational Safety and Health
Education and Information Division