Durable visible light-activated antiviral coatings for fabrics used for personal respirator such as the N95 mask.
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R43-OH-009459, 2010 Mar; :1-24
The FDA has recognized growing threats from infectious diseases in the hospital and community. As a precaution, to themselves and patients, caregivers wear personal protective equipment (PPE) such as respirator masks to minimize contact transmission onto facial skin or airborne inhalation of pathogenic organisms. Case-control studies conducted in Beijing and Hong Kong showed that wearing masks was independently associated with protection from SARS in a multivariate analysis. However, a study performed by the CDC showed definitive evidence of the transmission of virus particles from PPE to other people and surfaces in a hospital setting. Our goal was to develop an economical and manufacturable coating for personal protective equipment which will inactivate more than 99.9% of a challenge inoculum of influenza virus within one hour under normal conditions of use. Our approach was to immobilize [coat] photoactive dyes onto surfaces [filtration media]. These dyes when exposed to visible light catalyze the production of singlet oxygen from air [oxygen] and are known to inactivated viruses and bacteria. The preferred coating was developed from a suitable combination of dyes, attachment methods and filtration media. We determined that the most cost effective and active dye to use was Rose Bengal, a potent antiviral and bacterial agent. Literature methods used to modify Rose Bengal for immobilization to acrylate polymers proved to be unreliable, so an alternate synthetic pathway was developed. Rose Bengal was synthetically modified to attach either an acrylate or styry monomer to the dye and polymerized with other acrylate monomers to form a multifunctional acrylic polymer. This polymer contained reactive side chains which aided permanent bonding to nylon filtration media. Coating [dyeing] was achieved in a conventional fabric "dyeing" which can be scaled to full size manufacturing. The dye incorporated polymer has been synthesized in efficient 25 gallon batches and further scale-up should be straight forward. d further. This research enhanced the efficiency of the antiviral effect and permits development of cost-effective methods for commercial manufacture of the devices [N95 masks] while retaining marked antiviral properties.
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.