Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine.
Kelly-KA; Miller-DB; Bowyer-JF; O'Callaghan-JP
J Neurochem 2012 Sep; 122(5):995-1009
Upregulation of proinflammatory cytokines and chemokines in brain ("neuroinflammation") accompanies neurological disease and neurotoxicity. Previously, we documented a striatal neuroinflammatory response to acute administration of a neurotoxic dose of methamphetamine (METH), i.e. one associated with evidence of dopaminergic terminal damage and activation of microglia and astroglia. When we used minocycline to suppress METH-induced neuroinflammation, indices of dopaminergic neurotoxicity were not affected but suppression of neuroinflammation was incomplete.
Brain-function; Diseases; Neurotoxicity; Neurotoxic-effects; Drugs; Corticosteroids; Neurological-diseases; Neurological-reactions; Animals; Laboratory-animals
Journal of Neurochemistry