Rationale: Police officers represent 706,900 workers in the U.S. and have high rates of cardiovascular disease (CVD). Given associations between obesity and CVD, we evaluated a less well-established association between waist circumference and brachial artery reactivity (BAR), a measure of endothelial function and early CVD risk. Methods: Demographic, anthropometric, and risk factor data were collected during 1999-2000 in the Buffalo Cardio-Metabolic Occupational Police Stress Study. BAR was measured during 2001-2003 using standardized noninvasive ultrasound scans and was calculated as percent increase in brachial artery diameter after blood pressure cuff release. Gender-stratified regression models adjusted for age, smoking, and physical activity were used to examine trends in mean BAR across waist circumference tertiles. Due to limited sample size, effect modification by several factors was evaluated among all officers combined. Results: The study included 70 officers (57.1% men) with a mean age of 40.9 years. Adjusted mean BAR decreased (5.96%, 4.26%, 3.37%; P = 0.06) across increasing waist tertiles (80-89.4, 89.5-97.9, 98-126 cm) among men, but not women. Alcohol use was an effect modifier; officers who had intake above the median had a significant decline in adjusted mean BAR (5.56%, 5.20%, 2.12%; P = 0.01) across increasing waist tertiles, whereas those with lower intake did not. Further adjustment for gender attenuated this association. Conclusion: Results indicate larger waist circumference may be associated with reduction in BAR. Larger sample size and longitudinal study are needed to confirm this relationship.
Police-officers; Emergency-responders; Demographic-characteristics; Anthropometry; Risk-factors; Epidemiology; Statistical-analysis; Men; Women; Humans; Diagnostic-techniques; Diagnostic-tests; Cardiovascular-system-disease; Cardiovascular-function; Cardiovascular-disease; Cardiovascular-system-disorders