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An exposure-response analysis of respiratory disease risk associated with occupational exposure to chrysotile asbestos.
Stayner-L; Smith-R; Bailer-AJ; Gilbert-S; Steenland-K; Dement-J; Brown-D; Lemen-R
Ann Occup Hyg, Inhaled Particles VIII 1997 Jan; 41(Suppl 1):137-141
The results from these analyses clearly demonstrate a strong exposure-response relationship between chrysotile exposure and mortality from asbestosis and lung cancer, which is not surprising given the results from previous studies. The exposure-response relationship for lung cancer appeared to be linear on a multiplicative scale, whereas the exposure-response relationship for asbestosis appeared to be sub-linear. There was no statistical evidence for a threshold in either the lung cancer or asbestosis model. Thus the results from this analysis fail to provide any support for arguments that have been made for a threshold for the effects of chrysotile asbestos on lung cancer and asbestosis risks (Browne, 1986). Based on this analysis, the predictions of excess lifetime risk for white males exposed for 45 years at the recently revised OSHA standard of 0.1 fibers cc--1 was predicted to be approximately 5 per 1000 for lung cancer and 2 per 1000 for asbestosis. The lung cancer risks estimated in this analysis were substantially higher than what was observed in previous analyses of Quebec chrysotile miners and millers (McDonald et al., 1980, 1994). The reasons for these widely varying results are not known.
Asbestos-fibers; Occupational-exposure; Respiratory-system-disorders; Dose-response; Lung-cancer; Industrial-factory-workers; Asbestos-workers; Mortality-data
EID; DSHEFS; OD
Annals of Occupational Hygiene, Inhaled Particles VIII
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division