Animal model of (1-->3)-beta-glucan-induced pulmonary inflammation in rats.
Authors
Young-S-H; Castranova-V
Source
Toxicology of 1-->3-beta-glucans: glucans as a marker for fungal exposure. Young S-H, Castranova V, eds. Boca Raton, FL: CRC Press, 2005 Jan; :65-93
Link
NIOSHTIC No.
20040894
Abstract
Results of studies from our laboratory indicate that zymosan A (a crude form of [1-->3]-beta-glucans) can induce pulmonary inflammation in rats when inhaled. There is a direct dose-response and time course relationship between zymosan A exposure and development of pulmonary inflammation. The NaOH-soluble forms of zymosan A cause mild inflammation in rats, while NaOH-insoluble zymosan A induces a significant greater degree of pulmonary inflammation in rats. An open triple helix conformation of zymosan is more potent than a closed triple helix toward some assays. Pretreatment with particulate [1-->3]-beta-glucans inhibits pulmonary responses to subsequent LPS exposure. Most of the current [1-->3]-beta-glucan analysis methods can only analyze glucans in the soluble form (either by heat extraction or NaOH extraction or a combination of both). However, our studies indicate that the level of inflammation correlates well with the insoluble fraction of [1-->3]-beta-glucans but not with the soluble fraction of [1-->3]-beta-glucans. Therefore, there is a need to develop alternative methods for analysis the insoluble fraction of [1-->3]-beta-glucans.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.