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Peripheral nerve function and lower extremity muscle power in older men.
Ward-RE; Caserotti-P; Faulkner-K; Boudreau-R; Cawthon-PM; Newman-AB; Cauley-JA; Strotmeyer-ES
Gerontologist 2011 Nov; 51(Suppl 2):112
Decline in muscle power with age may be partly due to lower peripheral nerve (PN) function, particularly number and firing rate of motor units. We assessed cross-sectional relationships between maximal power/kg body weight (Nottingham power rig) and sensorimotor nerve function (peroneal/sural nerve conduction, monofilament testing, symptoms) in 568 men (mean age=77.2+/-5.1, BMI=28.2+/-4.0, power=1.87+/-0.6watts/kg) from the Osteoporotic Fractures in Men (MrOS) Study in Pittsburgh, PA. Covariates included age, body composition, comorbidities (e.g. diabetes, ankle arm index), lifestyle factors (e.g. physical activity), and grip strength. Higher compound muscle action potential (CMAP) and detection of 1.4g monofilament were associated with greater power/kg (both p<0.05). Having >2 PN symptoms (numbness/tingling, stabbing/burning/pain, open/persistent sores/gangrene) was associated with lower power/kg (p<0.01). Sural nerve conduction and motor latency were not associated with power/kg after adjustment. In these older men, CMAP, monofilament detection and PN symptoms were related to power/kg and may identify muscle function problems.
Nerve-function; Peripheral-nervous-system; Men; Age-factors; Age-groups; Extremities; Muscle-function; Physical-capacity; Sensory-motor-system; Peripheral-motor-system; Body-weight; Neuromotor-function; Neuromuscular-function
PA; MD; CA