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Hypersensitivity reactions to marijuana.
Tessmer-A; Berlin-N; Sussman-G; Leader-N; Chung-EC; Beezhold-D
Ann Allergy, Asthma, & Immun 2012 Apr; 108(4):282-284
In this study, marijuana hypersensitivity was demonstrated with a crude uncharacterized SPT reagent, andlarge wheal and flare responses were observed; suggesting type 1 sensitization to proteins of the cannabis plant. Five C sativa IgE-binding proteins have been reported, ranging from 10 to 68 kDa, using serum samples from an allergic patient, and a 9-kDa LTP has been positively identified. Some marijuana allergic patients have positive SPT results to ragweed, pigweed, and tomato plants, indicating possible cross-reactivity. Moreover, work-related contact urticaria has been reported in forensic science laboratory technicians handling marijuana. Several reports have implicated contamination with Aspergillus as a potential source of allergens in marijuana, although only 1 of our patients had SPT reactivity to Aspergillus. Addressing marijuana allergy is difficult when assessing patient exposure history because patients may not voluntarily disclose this information even when experiencing symptoms. Future studies with standardized extracts will be needed to determine the specific allergens associated with marijuana allergy and to better understand and develop strategies for treatment. Allergic reactions to marijuana appear to be increasing in prevalence given the increasing social use of marijuana and its expanding use for medical and ingestion purposes. Because some of the reactions are severe, it is important that clinicians address marijuana exposure when assessing a patient's exposure history.
Drug-therapy; Hallucinogens; Allergies; Allergens; Allergic-reactions; Humans; Skin-tests; Plant-substances; Plants; Medical-screening; Hypersensitivity
Issue of Publication
Annals of Allergy, Asthma, and Immunology
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division