Dermal absorption of finite doses of volatile compounds.
J Pharm Sci 2012 Jul; 101(7):2616-2619
Laplace domain solutions to a previously published finite dose skin diffusion model are presented. The purpose of the current analysis is to derive a simple algebraic expression quantifying the total mass that is systemically absorbed at infinite time after exposure, relative to the applied mass. The resulting expression is a function of two dimensionless parameters: f, the fractional depth within the skin surface through which the permeant is initially deposited, and ?, the ratio of maximum evaporation flux to maximum dermal flux. The result may be useful for dermal risk assessment as well as in the evaluation of cosmetic and pharmaceutical product performance.
Skin; Skin-absorption; Exposure-levels; Exposure-limits; Absorption-rates; Mathematical-models; Diffusion-analysis; Models; Risk-analysis; Risk-factors; Volatiles;
Author Keywords: diffusion; mathematical model; percutaneous; permeability; skin; solvent evaporation; absorption
H. Frederick Frasch, Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505
Journal of Pharmaceutical Sciences