Dermal absorption: Environmental Health Criteria 235.
Kielhorn-J; Melching-Kollmuss-S; Mangelsdorf-I; Bronaugh-R; Bunge-AL; Heylings-J; Kezic-S; Krüse-J; Mueller-U; Roberts-M; van de Sandt-JJM; Walters-KA; Williams-FM; Vickers-C
Kielhorn J, Melching-Kollmuss S, Mangelsdorf I, eds., Geneva: World Health Organization, 2006 Jan; :1-197
Dermal (percutaneous, skin) absorption is a global term that describes the transport of chemicals from the outer surface of the skin both into the skin and into the systemic circulation. This Environmental Health Criteria document presents an overview of dermal absorption and its application to the risk assessment of chemicals. In addition, it presents and discusses current topics of interest in the field of dermal absorption. Dermal absorption can occur from occupational, environmental, or consumer skin exposure to chemicals, cosmetics, and pharmaceutical products. In spite of the successes in interdisciplinary international harmonization to date, there are a number of aspects to be further improved and which remain as topics of discussion. These include the extent of intralaboratory and interlaboratory variation in in vitro and in vivo studies; the acceptance of QSPeRs; the reservoir effect of chemicals in the stratum corneum and its interpretation in risk assessment; the relevance of dermal absorption measurements to data required by risk assessors; and the use of the barrier integrity test for skin barrier function. Other topics that must be considered include dermal absorption in susceptible populations, the necessity for harmonization of skin notation, and the dermal absorption of nanoparticles. Recommendations are made by the Task Group concerning the benefits of using human skin over laboratory animal skin; study design and harmonization of methodology; correlation of in vitro and in vivo data and development of reliable prediction models; encouraging support, maintainance, and update of databases; and furthering the evaluation of QSARs for risk assessment purposes, and preparation of guidance on their use.
Skin-absorption; Skin-exposure; Skin-sensitivity; Skin-irritants; Skin; Risk-analysis
Kielhorn-J; Melching-Kollmuss-S; Mangelsdorf-I
Dermal absorption: environmental health criteria 235
Colorado School of Mines