Rhinosinusitis and mold as risk factors for asthma symptoms in occupants of a water-damaged building.
Park-J-H; Kreiss-K; Cox-Ganser-JM
Indoor Air 2012 Oct; 22(5):396-404
Mold exposure in damp buildings is associated with both nasal symptoms and asthma development, but progression of building-related (BR) rhinosinusitis symptoms to asthma is unstudied. We examined risk of developing BR-asthma symptoms in relation to prior BR-rhinosinusitis symptoms and microbial exposure among occupants of a damp building. We conducted four cross-sectional health and environmental surveys among occupants of a 20-story water-damaged office building. We defined BR-rhinosinusitis symptom (n=131) and comparison (n=361) groups from participants' first questionnaire responses. We compared the odds for development of BR-asthma symptoms between these two groups over the subsequent surveys, using logistic regression models adjusted for demographics, smoking, building tenure, and first survey exposures to fungi, endotoxin, and ergosterol. The BR-rhinosinusitis symptom group had higher odds for developing BR-asthma symptoms [odds ratio (OR)=2.2; 95% confidence interval (CI)=1.3-3.6] in any subsequent survey compared to those without BR-rhinosinusitis symptoms. The BR-rhinosinusitis symptom group with higher fungal exposure within the building had an OR of 7.4 (95% CI=2.8-19.9) for developing BR-asthma symptoms, compared to the lower fungal exposure group without BR-rhinosinusitis symptoms. Our findings suggest that rhinosinusitis associated with occupancy of water-damaged buildings may be a sentinel for increased risk for asthma onset in such buildings.
Respiratory-system-disorders; Bronchial-asthma; Nasal-disorders; Microorganisms; Microscopic-analysis; Molds; Health-surveys; Questionnaires; Risk-analysis; Demographic-characteristics; Mathematical-models; Smoking; Endotoxins; Fungi;
Author Keywords: Rhinosinusitis; mold exposure; asthma
Dr. Ju-Hyeong Park, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, MS 2800, 1095 Willowdale Rd., Morgantown, WV 26505-5820