Paducah Gaseous Diffusion Plant mortality study: job title analysis.
Chan MC; Hughes TS; Muldoon SB; Aldrich T; Rice C; Hornung R; Tollerud DJ
APHA 137th Annual Meeting and Exposition, November 7-11, 2009, Philadelphia, Pennsylvania. Washington, DC: American Public Health Association, 2009 Nov; :200086
The Paducah Gaseous Diffusion Plant (PGDP) is currently the only operating uranium enrichment facility in the U.S, and the only one that has not undergone an assessment of worker mortality. It was commissioned in 1952 as part of a U.S. government program to produce enriched uranium to fuel military reactors and produce nuclear weapons. Demographic, work history and vital status data were collected on 6820 workers. A total of 1674 deaths were identified. The Life Table Analysis System (LTAS) was used to analyze outcomes based on job title. Standardized Mortality Ratios (SMRs) and Standardized Risk Ratios (SRRs) were calculated analyzing the cohort for 92 causes of death. Job titles at the plant were condensed into 44 grouped job titles based on similarity of task and exposures. Analyses were further limited to job titles with a minimum of 5% of the person years of the whole cohort, resulting in 11 job titles analyzed. Lymphatic and hematopoietic cancers have been associated with low-dose radiation exposure and were of a-priori interest. All causes and all cancers outcomes had significantly lower SMRs than the referent population, reflecting a strong healthy worker effect. Non-significant elevations were found for lymphatic and hematopoietic cancers for the job titles Chemical Operator, Maintenance, and Security. Security had a significant elevation in Non-Hodgkin's lymphoma. Office workers had a significant elevation in colon cancer. Elevations in deaths due to Alzheimer's disease were found to reach significance for the cohort and the job titles Laboratory and Maintenance.
Uranium-compounds; Workers; Work-environment; Mortality-rates; Morbidity-rates; Nuclear-reactions; Nuclear-hazards; Nuclear-energy; Statistical-analysis; Epidemiology; Risk-factors; Exposure-limits; Exposure-levels; Cancer; Lymphatic-cancer; Lymphatic-system-disorders; Lymphatic-system; Hematopoietic-system; Radiation-contamination; Radiation-effects; Radiation-exposure; Radiation-hazards; Radiation-levels; Radiation-measurement; Radiation-properties; Radiation-sickness;
Author Keywords: Occupational Exposure; Outcomes Research
APHA 137th Annual Meeting and Exposition, November 7-11, 2009, Philadelphia, Pennsylvania
University of Louisville