Pathogenesis and disease mechanisms of occupational asthma.
Lummus-ZL; Wisnewski-AV; Bernstein-DI
Immunol Allergy Clin North Am 2011 Nov; 31(4):699-716
Occupational asthma (OA) is one of the most common forms of work-related lung disease in all industrialized nations. The clinical management of patients with OA depends on an understanding of the multifactorial pathogenetic mechanisms that can contribute to this disease. This article discusses the various immunologic and nonimmunologic mechanisms and genetic susceptibility factors that drive the inflammatory processes of OA.
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Bronchial-asthma; Pathology; Pathogenesis; Immune-reaction; Immunology; Genetic-factors; Genetics;
Author Keywords: Occupational asthma; Airway hyperresponsiveness; Workplace allergens; Immune mechanisms; Airway remodeling; Oxidative stress; Genetic susceptibility
David I. Bernstein, MD, Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, 3255 Eden Avenue, Cincinnati, OH 45267-0563, USA
Immunology and Allergy Clinics of North America
University of Cincinnati