Hazard and risk assessment of workplace exposure to engineered nanoparticles: methods, issues, and carbon nanotube case study.
Kuempel E; Castranova V
Assessing Nanoparticle Risks to Human Health, Micro & Nano Technologies Series. Ramachandran G, ed., Waltham, MA: William Andrew, 2011 Sep; :65-97
Toxicology data from experimental studies in animals are frequently used in risk assessment when human dose-response data are not available. Collaborations among industrial hygienists, toxicologists, risk assessors, and other disciplines provide an opportunity to develop an improved scientific data basis for assessing the risk of exposure to nanomaterials. In this chapter, the components of the risk assessment process are described, with focus on occupational risk assessment of inhaled particles. A case study is presented using rat subchronic inhalation data of multiwalled carbon nanotubes (MWCNT) to illustrate the application of risk assessment methods to engineered nanoparticles using currently available data. Issues in using these data in quantitative risk estimation are discussed, as are research needs to reduce the uncertainties in the risk assessment of occupational exposure to nanomaterials.
Nanotechnology; Risk-analysis; Quantitative-analysis; Dosimetry; Dose-response;
Author Keywords: Risk assessment paradigm; Hazard assessment; Dose-response assessment; Temporal extrapolation; Carbon nanotubes
Assessing Nanoparticle Risks to Human Health, Micro & Nano Technologies Series