Overview of AHR functional domains and the classical AHR signaling pathway: induction of drug-metabolizing enzymes.
The AH receptor in biology and toxicology. Pohjanvirta R, ed. Hoboken, NJ: Wiley, 2011 Dec; :33-45
This chapter contains sections titled: Introduction; Induction of CYP1A1 and the AHR Battery of DMES; Defining Major Components of CYP1A1 Induction; Molecular Characterization of AHR and ARNT; Other Components of Induction; The Classical Signaling Pathway of Gene Induction by AHR; Expanding Role of the AHR/ARNT/DRE Paradigm in AHR Biology; and, Conclusions
Metabolic-activation; Metabolism; Genes; Genetics;
Author Keywords: AHR; ligand-activated factor; AHR domains; signaling pathway; CYP1A1 induction; drug metabolizing
The AH receptor in biology and toxicology