NIOSHTIC-2 Publications Search

Overview of AHR functional domains and the classical AHR signaling pathway: induction of drug-metabolizing enzymes.

Authors
Ma-Q
Source
The AH receptor in biology and toxicology. Pohjanvirta R, ed. Hoboken, NJ: Wiley, 2011 Dec; :33-45
NIOSHTIC No.
20040117
Abstract
This chapter contains sections titled: Introduction; Induction of CYP1A1 and the AHR Battery of DMES; Defining Major Components of CYP1A1 Induction; Molecular Characterization of AHR and ARNT; Other Components of Induction; The Classical Signaling Pathway of Gene Induction by AHR; Expanding Role of the AHR/ARNT/DRE Paradigm in AHR Biology; and, Conclusions
Keywords
Metabolic-activation; Metabolism; Genes; Genetics; Author Keywords: AHR; ligand-activated factor; AHR domains; signaling pathway; CYP1A1 induction; drug metabolizing
Publication Date
20111201
Document Type
Chapter
Editors
Pohjanvirta-R
Fiscal Year
2012
ISBN No.
9780470601822
Identifying No.
B01182012
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
The AH receptor in biology and toxicology
State
WV
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division