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The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.
Kang-Sickel-J-CC; Butler-MA; Frame-L; Serdar-B; Chao-Y-CE; Egeghy-P; Rappaport-SM; Toennis-CA; Li-W; Borisova-T; French-JE; Nylander-French-LA
Biomarkers 2011 Nov; 16(7):590-599
We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p=0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p<0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.
Exposure-limits; Exposure-levels; Skin; Skin-exposure; Skin-irritants; Skin-sensitivity; Urinalysis; Naphthalenes; Biomarkers; Fuels; Author Keywords: Biomarkers; CYP2E1; dermal exposure; glutathione S-transferase mu 1 (GSTM1); glutathione S-transferase theta 1 (GSTT1); jet fuel (JP-8); keratin adduct; NAD(P)H:quinone oxidoreductase (NQO1); 1-naphthol; 2-naphthol; naphthalene; urine
Leena A. Nylander-French, Ph.D., CIH, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB #7431, Rosenau Hall, Chapel Hill, NC 27599-7431
Grant-Number-T42-CCT-422952; Grant-Number-T42-OH-008673; B11232011
Issue of Publication
Healthcare and Social Assistance; Services; Manufacturing
CO; CA; NC; OH; TX
University of North Carolina, Chapel Hill
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division