The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.
Kang-Sickel-J-CC; Butler-MA; Frame-L; Serdar-B; Chao-Y-CE; Egeghy-P; Rappaport-SM; Toennis-CA; Li-W; Borisova-T; French-JE; Nylander-French-LA
Biomarkers 2011 Nov; 16(7):590-599
We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p?=?0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p?0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.
Exposure-limits; Exposure-levels; Skin; Skin-exposure; Skin-irritants; Skin-sensitivity; Urinalysis; Naphthalenes; Biomarkers; Fuels;
Author Keywords: Biomarkers; CYP2E1; dermal exposure; glutathione S-transferase mu 1 (GSTM1); glutathione S-transferase theta 1 (GSTT1); jet fuel (JP-8); keratin adduct; NAD(P)H:quinone oxidoreductase (NQO1); 1-naphthol; 2-naphthol; naphthalene; urine
Leena A. Nylander-French, Ph.D., CIH, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB #7431, Rosenau Hall, Chapel Hill, NC 27599-7431
Grant-Number-T42-CCT-422952; Grant-Number-T42-OH-008673; B11232011
Healthcare and Social Assistance; Services; Manufacturing
University of North Carolina, Chapel Hill