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Flavoring-related lung disease: information for healthcare providers <a href="https://www.cdc.gov/niosh/docs/2012-148/"target="_blank"a>(superseded by 2012-148)</a>.
Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2012-107, 2011 Nov; :1-6
Severe obstructive lung disease has been identified in people who work with flavoring chemicals containing diacetyl, including butter flavoring. Cases of severe lung disease have occurred in microwave popcorn plants and flavoring production plants. Lung biopsies in some affected people have shown the presence of a rare condition; constrictive bronchiolitis obliterans (also referred to as constrictive bronchiolitis, obliterative bronchiolitis, and bronchiolitis obliterans). In some workers, fixed airways obstruction has been severe enough to be fatal.
Lung; Lung-disease; Lung-disorders; Lung-function; Lung-irritants; Lung-tissue; Chemical-hypersensitivity; Chemical-properties; Humans; Men; Women; Exposure-limits; Exposure-levels; Workers; Respiratory-system-disorders; Pulmonary-system-disorders; Pulmonary-disorders; Fibrogenicity; Fibrosis
DHHS (NIOSH) Publication No. 2012-107; B11232011
National Institute for Occupational Safety and Health
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division