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Dermal penetration potential of perfluorooctanoic acid (PFOA) in human and mouse skin.

Authors
Franko J; Meade BJ; Frasch HF; Barbero AM; Anderson SE
Source
J Toxicol Environ Health A 2012 Jan; 75(1):50-62
Link
https://doi.org/10.1080/15287394.2011.615108
NIOSHTIC No.
20039896
Abstract
Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) induces immune modulation, suggesting that this may be an important route of PFOA exposure. To investigate the dermal penetration potential of PFOA, serum concentrations were analyzed in mice following topical application. Statistically significant and dose-responsive increases in serum PFOA concentrations were identified. In vitro dermal penetration studies also demonstrated that PFOA permeates both mouse and human skin. Investigation into the mechanisms mediating PFOA penetration demonstrated that dermal absorption was strongly dependent upon the ionization status of PFOA. In addition, PFOA solid, but not 1% PFOA/acetone solution, was identified as corrosive using a cultured epidermis in vitro model. Despite its corrosive potential, expression of inflammatory cytokines in the skin of topically exposed mice was not altered. These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure.
Keywords
Biological-effects; Laboratory-animals; Laboratory-testing; Physical-reactions; Physiological-response; Physiological-testing; Skin-absorption; Skin-exposure; Skin-irritants; Skin-sensitivity; Skin-tests; Statistical-analysis; Dermal exposures; Models; Exposure levels; Risk factors; Animals; In vitro study; In vitro studies; Dermal absorption; Ionization; Acetones; Corrosives; Cytokines; Skin
Contact
Stacey E. Anderson, PhD, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
JTEHD6
Publication Date
20120101
Document Type
Journal Article
Email Address
Sanderson4@cdc.gov
Funding Type
Grant
Fiscal Year
2012
Identifying No.
Grant-Number-T01-OH-008431; B11232011
Issue of Publication
1
ISSN
1528-7394
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV
Performing Organization
West Virginia University
Page last reviewed: May 11, 2023
Content source: National Institute for Occupational Safety and Health Education and Information Division