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The effectiveness of using interferon-gamma release assays in screening immigration employees for latent tuberculosis infection.
de Perio MA; Niemeier RT; Groenewold MR
Int J Occup Environ Health 2011 Oct-Dec; 17(4):322-327
We assessed the prevalence of latent tuberculosis infection in immigration employees and compared two of the screening methods. Using a cross-sectional study design, we administered questionnaires regarding demographics, work, medical history, and tuberculosis risk factors to employees at two immigration facilities. Participants underwent tuberculin skin test (TST) placement and blood collection for the QuantiFERONTB Gold in-Tube (QFT-GIT) assay. Fifty-four employees underwent QFT-GIT and TST placement. All QFT-GIT results were negative, and three employees tested TST positive. Twenty-three (49 percent) of 47 employees requiring two-step TST testing underwent second TST placement. Return rates for first and second TST reading were 76 percent and 74 percent, respectively. The QFT-GIT completion rate was higher than that for TST (100 percent vs. 39 percent, P less than 0.001). Agreement between TST and QFTGIT was 94 percent. Immigration employees had low return rates for their TST reading and second TST placement. Performing the one-visit QFT-GIT has administrative and logistical advantages in this occupational group.
Medical-screening; Respiratory-system-disorders; Screening-methods; Health-surveys; Questionnaires; Employee-exposure; Employee-health; Demographic-characteristics; Infection-control; Disease-control; Disease-transmission; Skin-tests; Blood-tests; Diagnostic-tests; Risk-analysis; Risk-factors; Bioassays
Marie A. de Perio, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, R-10, Cincinnati, OH 45226
Issue of Publication
International Journal of Occupational and Environmental Health
Page last reviewed: September 4, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division