Pilot study for the investigation of personal breathing zone and dermal exposure using levels of polycyclic aromatic compounds (PAC) and PAC metabolites in the urine of hot-mix asphalt paving workers.
Osborn-LV; Snawder-JE; Olsen-LD; Kriech-AJ; Cavallari-JM; Herrick-RF; McClean-MD; Blackburn-GR
Polycycl Aromat Compd 2011 Aug; 31(4):173-200
As part of the design of a comprehensive study of hot-mix asphalt paving workers to investigate the relative contribution of personal breathing zone and dermal exposures to polycyclic aromatic compounds, a two-part pilot (Phase I) was performed. The pilot study was important to examine the sources of exposure, the chemical nature of these exposures, and their biological relevance through analysis of biomarkers in urine. Existing, modified, and new sampling and analytical techniques, used in concert with each other, were evaluated to help design the full-scale study (Phase II). Although subject numbers were limited, the air, dermal, and urine sampling, analytical results and field experience provided valuable guidance in the design and implementation of Phase II. An overview of methods used and developed from this study is provided. More details of those methods selected for Phase II are presented in complementary manuscripts. Results of Phase II will be the subject of future publications.
Construction; Construction-materials; Asphalt-cements; Asphalt-concretes; Asphalt-fumes; Construction-workers; Road-construction; Road-surfacing; Breathing; Breathing-atmospheres; Breathing-zone; Dermatology; Skin; Skin-exposure; Skin-irritants; Polycyclic-aromatic-hydrocarbons; Biological-effects; Biomarkers; Urinalysis; Sampling; Sampling-equipment; Sampling-methods; Analytical-instruments; Analytical-processes; Metabolites; Inhalants; Inhalation-studies;
Author Keywords: asphalt paving; dermal; inhalation; polycyclic aromatic compounds
Linda V. Osborn, Heritage Research Group, 7901 West Morris Street, Indianapolis, Indiana 46231, USA
Polycyclic Aromatic Compounds