Acute effects of COREXIT EC9500A on cardiovascular functions in rats.
Krajnak K; Kan H; Waugh S; Miller GR; Johnson C; Roberts JR; Goldsmith WT; Jackson M; McKinney W; Frazer D; Kashon ML; Castranova V
J Toxicol Environ Health, A 2011 Nov; 74(21):1397-1404
These studies characterized cardiovascular responses after an acute inhalation exposure to COREXIT EC9500A, the oil dispersant used in the Deepwater Horizon oil spill. Male Sprague-Dawley rats underwent a single 5-h inhalation exposure to COREXIT EC9500A (average exposure level 27.12 mg/m(3)) or air. On d 1 and 7 following the exposure, rats were implanted with indwelling catheters and changes in heart rate and blood pressure were assessed in response to increasing levels of adrenoreceptor agonists. A separate group of rats was euthanized at the same time points, ventral tail arteries were dissected, and vascular tone along with dose-dependent responses to vasoconstricting and dilating factors were assessed in vitro. Agonist-induced dose-dependent increases in heart rate and blood pressure were greater in COREXIT EC9500A-exposed than in air-exposed rats at 1 d but not 7 d after the exposure. COREXIT EC9500A exposure also induced a rise in basal tone and reduced responsiveness of tail arteries to acetylcholine-induced vasodilation at 1 d but not 7 d following the exposure. These findings demonstrate that an acute exposure to COREXIT EC9500A exerts transient effects on cardiovascular and peripheral vascular functions.
Exposure-assessment; Laboratory-animals; Laboratory-testing; Cleaning-compounds; Dispersion; Cardiovascular-function; Cardiovascular-function-tests; Cardiovascular-system; Crude-oil; Cardiovascular-system-disorders; Animal-studies; Animals; Oils; Petroleum-oils; Petroleum-products; Petroleum; Inhalants; Inhalation-studies; Exposure-levels; Exposure-methods; In-vitro-study; Dose-response; Heart; Heart-rate; Blood-pressure; Chemical-cleaning; Acute-toxicity
Kristine Krajnak, PhD, Engineering and Controls Technology Branch, Health Effects Laboratory Division, 1095 Willowdale Rd, MS2027, Morgantown WV 26505, USA
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Journal of Toxicology and Environmental Health, Part A: Current Issues