Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers.
Friesen-MC; Costello-S; Thurston-SW; Eisen-EA
Am J Ind Med 2011 Jun; 54(6):450-460
Background: Metalworking fluids (MWF) - straight, soluble, and synthetic - have overlapping components. We derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides, and nitrosamines to account for this overlap and examined their relations with cancer incidence. Methods: An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios were estimated for each cancer and cumulative exposure (lagged) to each new metric; soluble MWF contributed variably to several metrics with weight k = 0-1. Results: For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH (k = 0). Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin. Conclusions: Our findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies.
Analytical-processes; Automotive-industry; Biocides; Biohazards; Biological-effects; Biological-monitoring; Biological-systems; Biostatistics; Cancer-rates; Chemical-hypersensitivity; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Metal-compounds; Metal-industry-workers; Metal-poisoning; Metal-workers; Metalworking-fluids; Metalworking-industry; Mortality-data; Mortality-rates; Occupational-diseases; Occupational-exposure; Occupational-hazards; Occupational-health; Quantitative-analysis; Risk-analysis; Statistical-analysis; Work-areas; Work-environment; Worker-health; Work-operations; Work-organization; Work-performance; Workplace-studies;
Author Keywords: metalworking fluids; polycyclic aromatic hydrocarbons; cancer incidence; cohort study; endotoxin; biocides; nitrosamines
Ellen A. Eisen, ScD, Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360
American Journal of Industrial Medicine
University of California, Berkeley