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Toenail, blood, and urine as biomarkers of manganese exposure.
Laohaudomchok-W; Lin-X; Herrick-RF; Fang-SC; Cavallari-JM; Christiani-DC; Weisskopf-MG
J Occup Environ Med 2011 May; 53(5):506-510
Objective: This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers. Methods: Air measurement data and work histories were used to determine manganese exposure over a work shift and cumulative exposure. Toenail samples (n = 49), as well as blood and urine before (n = 27) and after (urine, n = 26; blood, n = 24) a work shift were collected. Results: Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in 7 to 9, 10 to 12, and 7 to 12 months before toenail clipping date, but not 1 to 6 months. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese. Conclusions: Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical work shift.
Biomarkers; Cell-biology; Cellular-reactions; Construction; Construction-industry; Construction-workers; Exposure-assessment; Exposure-levels; Health-hazards; Manganese-compounds; Mathematical-models; Physical-reactions; Physiological-response; Reaction-rates; Statistical-analysis
Wisanti Laohaudomchok, ScD, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 3rd Floor-E, 401 Park Dr, Boston, MA 02215
Grant; Construction; Cooperative Agreement
Issue of Publication
Journal of Occupational and Environmental Medicine
MD; MA; CO
CPWR - The Center for Construction Research and Training, Silver Spring, Maryland