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Validation of a passive sampler for ketones.

Tsai-S; Que Hee-S
American Industrial Hygiene Conference and Exposition, June 5-11, 1999, Toronto, Ontario, Canada. Fairfax, VA: American Industrial Hygiene Association, 1999 Jun; :20
O-(2.3,4.5.6-pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA) has been used to analyze aldehydes in water because of its fast quantitative reaction to form oximes suitable for detection at the picogram (pg) level by gas chromatography/mass spectrometry (GCIMS) and gas chromatography/electron capture detection (GC/ECD). The PFBHA method also has been used to chemisorb aldehydes in air samples by dynamic sampling as well as passive sampling. The present aim was to validate a new ketones passive sampler for personal sampling in the environmental/industrial hygiene field. Cyclohexanone, diethyl ketone, ethyl butyl ketone, methyl n-amyl ketone, methyl n-butyl ketone, methyl ethyl ketone, methyl isopropyl ketone, and methyl propyl ketone were tested. A 13-mm diameter and 0.2-cm-thick pellet of PFBHA coated Tenax GC (1 0%, w/w) was made by a hand press. The sampler has a silicone membrane on top and a diffusion path length of 1.1 cm. The sampling constant was determined by exposures at known face velocities (20 to 70 fpm) at known vapor concentrations about the permissible exposure limit (PEL) as generated by a syringe pump at constant injection rate into pure air of known flow rate, and diluted appropriately before the exposure chamber. The PFBHA-ketone oximes were desorbed by hexane, and determined by selected ion monitoring GC/MS at m/z 181. The desorption efficiencies for wet ketones spiking were 87.2 +/- 7.0%, cyclohexanone; 91.1 +/- 3.9%, diethyl ketone; 98.0 +/- 3.2%, ethyl butyl ketone; 93.3 +/- 2.7%, methyl n-amyl ketone; 107.00 +/- 0.14%, methyl n-butyl ketone; 90.0 +/- 4.0%, methyl ethyl ketone; 92.8 +/- 5.6%, methyl isopropyl ketone; and 92.5 +/- 2.6%, methyl propyl ketone. The experimental sampling rates in mL/min were 4.07 +/- 0.49. cyclohexanone; 6.30 +/- 0.59, diethyl ketone; 6.31 +/- 0.31, ethyl butyl ketone; 3.78 +/- 0.25, methyl n-amyl ketone; 3.43 +/- 0.19, methyl n-butyl ketone; 6.48 +/- 0.64, methyl ethyl ketone; 4.37 +/- 0.43, methyl isopropyl ketone; and 4.57 +/- 0.17, methyl propyl ketone.
Airborne-particles; Air-monitoring; Air-samples; Air-sampling; Air-sampling-techniques; Environmental-exposure; Exposure-assessment; Gas-chromatography; Indoor-environmental-quality; Industrial-environment; Laboratory-testing; Mass-spectrometry; Quantitative-analysis; Sampling-methods; Statistical-analysis; Vapor-detectors; Vapor-volume; Water-sampling
108-94-1; 96-22-0; 591-78-6; 78-93-3; 108-10-1; 107-87-9; 110-43-0
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Research Tools and Approaches: Exposure Assessment Methods
Source Name
American Industrial Hygiene Conference and Exposition, June 5-11, 1999, Toronto, Ontario, Canada
Performing Organization
University of California Los Angeles, Los Angeles, CA
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division