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Validation of a dynamic personal sampler for chloroacetone.
Lin-YW; Que Hee-S
American Industrial Hygiene Conference and Exposition, May 9-15, 1998, Atlanta, Georgia. Fairfax, VA: American Industrial Hygiene Association, 1998 May; :56
Dynamic air sampling for aldehydes using derivatization with O-(2,3,4,S,6-pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA) has been developed with more than 90% recovery for several aldehydes. The other important carbonyl compounds, ketones, can also form the O-oxime derivatives with PFBHA. They may be positive interferences in the aldehyde sampling test. The aim of this study was to validate the dynamic personal air sampling method for chloroacetone vapors and to assess possible application to other ketones. Tenax TA (80/100 mesh) was coated with 20% (w /w) PFBHA by rotary evaporation. Coated 200-mg solid sorbent was packed into 7-cm long Pyrex glass tubes (7-mm OD and S-mm ID) with Pyrex glass wool layers at both ends. Desorption efficiency was tested by spiking specific amounts of chloroacetone in a 4-mL vial containing 200- mg coated sorbents then left at room temperature (211C) for more than 12 hours. The sampling tube was connected to a 10-L gas bag with 1 ppm and 5 ppm of chloroacetone vapor. A calibrated personal sampling pump was connected to the other side of the packed sampler at 50 mL/min sampling rate. Different sampling durations were tested to investigate the maximum capacity of the samplers. Each test was performed at least in triplicate. The PFBHA chloroacetone oxime was desorbed by hexane with agitation at least 2 minutes, and analyzed by gas chromatography/electron capture detection (GC/ECD). The lowest quantitative level (LQL) was SOO pg. The desorption efficiency was 96.1 +/- 5.8%. The recovery percentages were IDS +/- 2% for 15 ppm-min, 93.9 +/- S.6% for 45 ppm-min, 97.S +/- 4.S% for 60 ppm-min, 90.9 +/- 8.9% for ISO ppm-min, 89.3 +/- 6.1% for 180 ppm-min, 96.8 +/- 5.S% for 210 ppm-min, 99.5 +/- 2.9% for 240 pp-min, and 97.8 +/- 3.6% for 270 ppm-min. Each sampling tube provided 0.16 mmole PFBHA for reaction and the validated capacity of chloroacetone was 5.48 x 10-4 mmole or a molar ratio of PFBHA to chloroacetone of 290:1, whereas a ratio of 10:1 sufficed for aldehydes. This may be due to the steric factors of ketones. More ketones need to be investigated.
Airborne-particles; Air-monitoring; Air-quality-measurement; Air-sampling; Air-sampling-techniques; Chemical-hypersensitivity; Chemical-reactions; Exposure-assessment; Gas-chromatography; Laboratory-techniques; Laboratory-testing; Mathematical-models; Quantitative-analysis; Sampling-methods; Statistical-analysis; Vapor-detectors; Vapor-volume
Research Tools and Approaches: Exposure Assessment Methods
American Industrial Hygiene Conference and Exposition, May 9-15, 1998, Atlanta, Georgia
University of California Los Angeles, Los Angeles, CA
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division