Characterization of frequency-dependent responses of sensory nerve function to repetitive vibration.
Krajnak-K; Waugh-S; Johnson-C; Miller-R; Li-S; Kashon-ML
Can Acoust 2011 Feb; 39(2):92-93
Both epidemiological (1) and experimental studies (2) suggest that the ISO 5349 frequency weighting curve may not place enough weight on exposure to mid-range vibration frequencies (i.e., 100-500 Hz). Data from rat vibration studies demonstrated the risk of developing vibration-induced vascular dysfunction is greater in rats exposed to vibration at 125 or 250 Hz than in rats exposed to vibration at 62.5 Hz (3). Vibration also affects peripheral nerve function. However, the frequency-dependent effects of vibration on injury to the peripheral nervous system have not been examined. The goal of this study was to characterize the frequency-dependent effects of repeated vibration exposures (i.e., 10 days) on peripheral nerve function and biology.
Biological-factors; Biomechanics; Epidemiology; Exposure-assessment; Exposure-levels; Hand-injuries; Laboratory-animals; Laboratory-testing; Nervous-system; Nervous-system-function; Neuromuscular-function; Physiological-effects; Physiological-response; Posture; Repetitive-work; Vibration-effects; Vibration-exposure;
Author Keywords: Gene expression; Polymerase chain reaction; Rats; Ad libitum; Candidate genes; Different frequency; Frequency-dependent; Peripheral nerves; Quantitative PCR; Sensory nerves; Sprague-Dawley rats; Transcutaneous electrical stimulation; Vibration exposure
Engineering and Engineering & Control Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia, USA