Chemical process based reconstruction of exposures for an epidemiological study. III. Analysis of industrial hygiene samples.
Hall-TA; Esmen-NA; Jones-EP; Basara-H; Phillips-ML; Marsh-GM; Youk-AO; Buchanich-JM; Leonard-RC
Chem-Biol Interact 2007 Mar; 166(1-3):277-284
As part of an historical cohort study to investigate the mortality experience of industrial workers exposed to chloroprene (beta-CD) and other substances, all available industrial hygiene exposure monitoring data were collected and summarized. From discussions with on-site industrial hygiene personnel, it was apparent that these data were not collected for epidemiological purposes and, therefore, their use in characterization of exposures was problematic as the data mostly pertained to samples collected to investigate the performance of specific tasks. These data were, however, informative for validating the exposure modeling process used to estimate historical exposures. The data summarized below clearly indicate that exposures to beta-CD were lowered across the time period of this study. Typically, the exposures recorded were less than the occupational exposure limits of the periods in which the exposures were recorded. Additionally, exposure measurements recorded in the recent past do not represent the exposure actually experienced by the worker as a strict personal protective equipment use program has been in place for the facilities studied since the mid-1980s.
Industrial-exposures; Exposure-levels; Exposure-limits; Models; Monomers; Personal-protective-equipment; Mortality-data; Mortality-rates; Epidemiology;
Author Keywords: Chloroprene; Cohort study; Industrial hygiene; Exposure
Thomas A. Hall, Department of Occupational and Environmental Health, College of Public Health, University of Oklahoma, Oklahoma City, OK 93041
University of Illinois-Chicago