Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.
Tkach-AV; Shurin-GV; Shurin-MR; Kisin-ER; Murray-AR; Young-SH; Star-A; Fadeel-B; Kagan-VE; Shvedova-AA
ACS Nano 2011 Jun; 5(7):5755-5762
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naive T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
Nanotechnology; Nanotubes; Nanoparticles; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Lung-cells; Lung-disorders; Lung-tissue; Cell-damage; Cellular-function; Cellular-reactions; In-vivo-study; Immune-reaction; Immune-system; In-vitro-study; Cell-alteration; Cytology;
Author Keywords: dendritic cells; nanoparticles; immune system; immunosuppression; nanotubes
Alexey V. Tkach, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
University of Pittsburgh at Pittsburgh