NIOSHTIC-2 Publications Search

NIOSH skin notation (SK) profile: hydrogen fluoride/hydrofluoric acid (HF) [CAS No. 7664-39-3].

Dotson GS
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2011-137, 2011 Apr; :1-8
This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with HF and (2) the rationale behind the hazard-specific skin notation (SK) assignment for HF. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to HF. A literature search was conducted through July 2010 to identify information on HF, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to HF. HF is potentially capable of causing both systemic toxicity and direct adverse effects on the skin following dermal exposure. A critical review of available data provides evidence that skin contact with HF may be extremely hazardous and life-threatening, causing severe skin corrosion and acute systemic toxicity. NIOSH has designated HF with the following SK assignment: SK: SYS (FATAL)-DIR (COR). Table 1 provides an overview of the critical effects and data used to develop the SK assignment for HF. The following section provides additional detail about the potential health hazards of skin contact with HF and the rationale behind the SK assignment.
Skin; Skin-absorption; Skin-exposure; Skin-irritants; Chemical-analysis; Chemical-composition; Chemical-kinetics; Chemical-properties; Chemical-reactions; Chemical-structure; Health-hazards; Biological-effects; Dermatology; Exposure-assessment; Dose-response; Toxic-dose; Toxic-effects; Carcinogenicity; Kinetics; Sensitization; Reproductive-effects; Immunologic-disorders; Developmental-disorders; Fluoride-compounds; Acids; Surveillance-programs; Dermal-exposure; Dermal-absorption
Publication Date
Document Type
Numbered Publication; Skin Notation Profile
Fiscal Year
NTIS Accession No.
Identifying No.
DHHS (NIOSH) Publication No. 2011-137
NIOSH Division
Source Name
National Institute for Occupational Safety and Health
Page last reviewed: March 18, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division