NIOSH skin notation (SK) profile: phenol [CAS No. 108-95-2].
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2011-136, 2011 Apr; :1-12
This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with Phenol and (2) the rationale behind the hazard-specific skin notation (SK) assignment for Phenol. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to Phenol. A literature search was conducted through July 2010 to identify information on Phenol, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to Phenol. Phenol is potentially capable of causing both systemic toxicity and direct adverse effects on the skin following dermal exposure. A critical review of available data indicates that contact of a significant area of skin with subjectively low concentrations of phenol (5-6%) may be extremely hazardous and life-threatening [ATSDR 2008]. Undiluted phenol or solutions containing more than 3% phenol are capable of causing skin corrosion, whereas diluted solutions (1 to 3% phenol) are irritating to the skin [European Parliament 2008]. NIOSH has designated phenol with the following SK assignment: SK: SYS (FATAL)-DIR (COR). Table 1 provides an overview of the critical effects and data considered in the development of this SK assignment. The following section provides additional detail about the potential health hazards of skin contact with phenol and the rationale behind the SK assignment.
Skin; Skin-absorption; Skin-exposure; Skin-irritants; Chemical-analysis; Chemical-composition; Chemical-kinetics; Chemical-properties; Chemical-reactions; Chemical-structure; Health-hazards; Biological-effects; Dermatology; Exposure-assessment; Dose-response; Toxic-dose; Toxic-effects; Carcinogenicity; Kinetics; Sensitization; Reproductive-effects; Immunologic-disorders; Developmental-disorders; Phenols; Dermal-exposure; Dermal-absorption
Numbered Publication; Skin Notation Profile
NTIS Accession No.
DHHS (NIOSH) Publication No. 2011-136
National Institute for Occupational Safety and Health