NIOSHTIC-2 Publications Search

Pesticides, chromosomal aberrations, and non-Hodgkin's lymphoma.

Chiu BC-H; Blair A

J Agromedicine 2009 Apr; 14(2):250-255

https://doi.org/10.1080/10599240902773140

20038733

An excessive incidence of non-Hodgkin's lymphoma (NHL) has been reported among farmers and other occupational groups working with pesticides. Some pesticides exhibit immunotoxic and genotoxic activities. Individuals exposed to pesticides have also been found to have an increased prevalence of chromosomal abnormalities including the t(14;18)(q32;q21), one of the most common chromosomal abnormalities in NHL. Two recent epidemiologic studies reported that the association between pesticide exposures and risk of NHL was largely limited to NHL cases with the chromosomal translocation t(14;18). This review summarizes the findings from these epidemiologic studies, speculates on implications, and suggests the research needed to clarify the role of pesticides in NHL.

Agricultural-chemicals; Agricultural-industry; Agricultural-processes; Agricultural-workers; Agriculture; Cell-metabolism; Cell-morphology; Cellular-reactions; Chemical-hypersensitivity; Demographic-characteristics; Environmental-hazards; Epidemiology; Families; Farmers; Genotoxic-effects; Health-hazards; Immune-reaction; Immune-system-disorders; Immunochemistry; Medical-monitoring; Pesticides-and-agricultural-chemicals; Statistical-analysis; Work-environment; Worker-health; Author Keywords: Chromosomal abnormalities; epidemiology; lymphoma; pesticides; t(14;18)

Brian C.-H. Chiu, PhD, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611- 4402, USA

20090401

Journal Article

bchiu@northwestern.edu

Grant

2009

Grant-Number-R13-OH-009571

2

1059-924X

Journal of Agromedicine

WI; MD; IL

Marshfield Clinic