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Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments.
Lebouf RF; Stefaniak AB; Chen BT; Frazer DG; Virji MA
Nanotoxicology 2011 Dec; 5(4):687-699
Measurement of the surface area of airborne nanoparticles as administered to an experimental subject is critical for characterizing exposures during inhalation experiments. A filter-based surface area measurement methodology is described herein that allows for such determinations. Krypton gas adsorption was used to determine total particle surface area. Track-etched polycarbonate 0.4 µm pore filters were chosen as the collection substrate for metal oxide particles due to their highly reproducible surface areas and low background weights. The subject nanomaterials included two different batches of ultrafine TiO(2), TiO(2) nanorods, and SiO(2). The instrument detection limit for surface area was 200 cm(2) (0.02 m(2)). Ninety percent confidence interval estimates of method accuracy were 17.7-23.5% with a point estimate of 20.8%. The filter-based surface area measurement strategy is demonstrated to be a viable sampling and analysis methodology that provides much needed physical characterization information of particles as administered in an animal inhalation chamber.
Nanotechnology; Toxicology; Toxic-materials; Airborne-particles; Inhalants; Inhalation-studies; Exposure-assessment; Surface-properties; Measurement-equipment; Gas-adsorption; Gas-filters; Metal-oxides; Dioxides; Analytical-chemistry; Analytical-methods; Sampling; Sampling-equipment; Sampling-methods; Air-sampling-techniques; Physical-properties; Laboratory-testing; Silicon-compounds; Author Keywords: Nanoparticles; surface area; ultrafine titanium dioxide; sampling methodology
Ryan F. LeBouf, PhD, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505, USA
7439-90-9; 13463-67-7; 7631-86-9