C-reactive protein, interleukin-6, and posttraumatic stress disorder symptomology in urban police officers.
McCanlies-EC; Araia-SK; Joseph-PN; Mnatsakanova-A; Andrew-ME; Burchfiel-CM; Violanti-JM
Cytokine 2011 Jul; 55(1):74-78
Our aim was to examine the relationship between the level of the inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and posttraumatic stress disorder (PTSD) symptomology in a random sample of 115 police officers. CRP was measured in citrated plasma using a particle enhanced immunonepholometric assay and IL-6 was measured in serum with a solid-phase quantitative sandwich ELISA. The presence of high PTSD symptomology was defined as having an Impact of Event Scale score (IES) of > / = 26 compared to<26 (low PTSD symptomology). 28% of the officers had high PTSD symptomology. Mean levels of CRP and IL-6 did not differ significantly between officers with high PTSD symptomology and those with low symptomology (CRP: 0.76 mg/l vs. 0.97 mg/l; IL-6: 2.03 pg/ml vs. 1.74 pg/ml). We found no association of CRP and IL-6 levels with PTSD symptomology. This study was limited by sample size and its cross-sectional study design. A lack of association may occur if either CRP or IL-6 is elevated only at the onset of PTSD symptomology, or if inflammation is related to specific key components that define PTSD. Further research examining these relationships in a larger population may be worthwhile.
Cytology; Proteins; Stress; Behavioral-disorders; Immune-system; Immunochemistry; Job-stress; Police-officers; Law-enforcement-workers; Bioassays;
Author Keywords: Police; Posttraumatic stress disorder (PTSD); C-reactive protein (CRP); Interleukin-6 (IL-6); Inflammatory markers
Erin C. McCanlies, NIOSH/CDC, 1095 Willowdale Road, M/S 4050, Morgantown, WV 26505, USA
Services: Public Safety
University of New York at Buffalo