Nanoindentation measurement of articular cartilage from an in vivo loading model.
Li-C; King-KB; Pruitt-LA
Trans Annu Meet Orthop Res Soc 2008 Mar; 54:0649
Repetitive and forceful hand tasks can give rise to joint pain and induce upper musculoskeletal diseases. Measuring the effects of loading on the mechanical properties of cartilage helps relate exposure to outcome, as well as improve assessment and intervention of disease. Recent efforts have used nanoindentation to measure the local mechanical properties of cartilage in small models such as the rabbit metacarpophalangeal joint (MCP). However, there are challenges to interpreting the measured data, as standardized testing protocols and analysis methods for soft tissue nanoindentation are yet to be established. This work presents an alternative measurement method using nanoindentation, and compares it to the conventional Oliver-Pharr method (O-P) for evaluating the elastic modulus of articular cartilage from an in vivo joint flexion model.
Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Musculoskeletal-system-disorders; Biomechanics; Exposure-assessment; Nanotechnology
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Transactions of the Annual Meeting of the Orthopaedic Research Society
University of California - San Francisco