Cyclical in vivo loading increases cartilage proteoglycan content in the rabbit metacarpophalangeal joint.
Saadat-E; Majumdar-S; Burghardt-A; King-KB
Trans Annu Meet Orthop Res Soc 2006 Mar; 52:1352
The composition of the extracellular matrix of cartilage dictates its mechanical properties. Proteoglycans (PG) and collagen are two important structural components of the cartilage extracellular matrix. The ability to measure changes both in the amount and distribution of cartilage matrix constituents is essential in understanding early pathological changes of joint diseases. Previous studies have examined the biosynthetic response of articular cartilage with cyclical loading of osteochondral explants in vitro. We have developed a novel method of repetitive joint flexion and loading to examine the biosynthetic response of cyclical loading in vivo. This study examines the change in the amounts of proteoglycans and collagen in articular cartilage resulting from in vivo cyclical loading using Fourier transform infrared (FTIR) imaging spectroscopy.
In-vivo-studies; Models; Injuries; Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system-disorders; Biomechanics
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Transactions of the Annual Meeting of the Orthopaedic Research Society
University of California - San Francisco