Antimüllerian hormone as a predictor of natural fecundability in women aged 30-42 years.
Steiner-AZ; Herring-AH; Kesner-JS; Meadows-JW; Stanczyk-FZ; Hoberman-S; Baird-DD
Obstet Gynecol 2011 Apr; 117(4):798-804
OBJECTIVE: To generate estimates of the association between markers of ovarian aging and natural fertility in a community sample at risk for ovarian aging. METHODS: Women aged 30-44 years with no history of infertility who had been trying to conceive for less than 3 months provided early-follicular phase serum and urine (N=100). Subsequently, these women kept a diary to record menstrual bleeding and intercourse and conducted standardized pregnancy testing for up to 6 months. Serum was analyzed for estradiol, follicle-stimulating hormone (FSH), antimullerian hormone, and inhibin B. Urine was analyzed for FSH and estrone 3-glucuronide. Diary data on menstrual cycle day and patterns of intercourse were used to calculate day-specific fecundability ratios. RESULTS: Sixty-three percent of participants conceived within 6 months. After adjusting for age, 18 women (18%) with serum antimullerian hormone levels of 0.7 ng/mL or less had significantly reduced fecundability given intercourse on a fertile day compared with women with higher antimullerian hormone levels (fecundability ratio 0.38; 95% confidence interval [CI] 0.08-0.91). The day-specific fecundability for women with early-follicular phase serum FSH values greater than 10 milli-international units/mL compared with women with lower FSH levels was also reduced, although nonsignificantly (11% of women affected; fecundability ratio 0.44; 95% CI 0.08-1.10). The association with urinary FSH was weaker (27% women affected; fecundability ratio 0.61; 95% CI 0.26-1.26), and the associations for the other markers were weaker still. CONCLUSION: Early-follicular phase antimullerian hormone appears to be associated with natural fertility in the general population.
Age-factors; Age-groups; Biological-systems; Cell-biology; Cytology; Medical-monitoring; Medical-screening; Pregnancy; Reproductive-system; Reproductive-system-disorders; Statistical-analysis
Anne Z. Steiner, MD, MPH, University of North Carolina, CB #7570, 4001 Old Clinic Building, Chapel Hill, NC 27599
Agriculture, Forestry and Fishing; Mining
Obstetrics and Gynecology