Beta-2-microglobulin: renal biomarker of workplace U exposure.
Pinney SM; Rice C; Horn P; Pesce A
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-007976, 2008 Dec; :1-5
This study explored uses of beta-2-microglobulin as a biomarker for uranium exposure using a laboratory data and occupational history information previously collected from a population of over 2200 workers. Clinical reference intervals for this exposed population were calculated using traditional and recently developed methods incorporating outlier detection and a robust approach. Uranium exposure was characterized by several approaches. NIOSH developed estimates for job title specific exposure levels will be used in conjunction with calendar year, duration and length of employment to assign one measure of exposure to each worker. Site work location for each period of employment was used to assign a probability of exposure to several different chemical forms of uranium present at the site. In statistical analyses designed to evaluate the association between parameters of uranium exposure (amount, duration, age at exposure and chemical form) and level of urinary beta-2-microglobulin, we found that urinary log beta-2-microglobulin was associated with total cumulative exposure to uranium (p<0.0001). Log of serum BUN and creatinine, and plasma glucose, were not associated with uranium exposure. Age and gender were included in all models, and were significant parameters for serum BUN and creatinine, and plasma glucose, but not urinary beta-2-microglobulin. Both urinary protein and occult hematuria were significantly associated with uranium exposure.
Biomarkers; Uranium-compounds; Urinalysis; Urine-chemistry; Models; Demographic-characteristics; Statistical-analysis; Epidemiology
Susan M. Pinney, PhD, Department of Environmental Health, University of Cincinnati College of Medicine, PO Box 670056, Cincinnati, Ohio 45267-0056
Final Grant Report
NTIS Accession No.
National Institute for Occupational Safety and Health
University of Cincinnati