Beta-2-microglobulin: renal biomarker of workplace U exposure.
Authors
Pinney SM; Rice C; Horn P; Pesce A
Source
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-007976, 2008 Dec; :1-5
This study explored uses of beta-2-microglobulin as a biomarker for uranium exposure using a laboratory data and occupational history information previously collected from a population of over 2200 workers. Clinical reference intervals for this exposed population were calculated using traditional and recently developed methods incorporating outlier detection and a robust approach. Uranium exposure was characterized by several approaches. NIOSH developed estimates for job title specific exposure levels will be used in conjunction with calendar year, duration and length of employment to assign one measure of exposure to each worker. Site work location for each period of employment was used to assign a probability of exposure to several different chemical forms of uranium present at the site. In statistical analyses designed to evaluate the association between parameters of uranium exposure (amount, duration, age at exposure and chemical form) and level of urinary beta-2-microglobulin, we found that urinary log beta-2-microglobulin was associated with total cumulative exposure to uranium (p<0.0001). Log of serum BUN and creatinine, and plasma glucose, were not associated with uranium exposure. Age and gender were included in all models, and were significant parameters for serum BUN and creatinine, and plasma glucose, but not urinary beta-2-microglobulin. Both urinary protein and occult hematuria were significantly associated with uranium exposure.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.