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Neuronal synaptic and cytoskeletal protein aberration following acute inhalation exposure to the oil dispersant COREXIT® EC9500A.
Sriram K; Jefferson AM; Lin GX; Goldsmith WT; Jackson M; Frazer DG; Robinson VA; Castranova V
FASEB J 2011 Apr; 25(Meeting Abstracts):1016.4
Consequent to the Gulf oil spill, there is an emergent concern about the short- and long-term adverse health effects of exposure to oil, weathered-oil products and dispersants among the workforce employed to contain and clean-up the spill. Workers are at risk for exposure primarily via inhalation of volatile or non-volatile aerosolized components. These inhaled fractions can potentially translocate to the brain via olfactory or systemic circulation causing nervous system abnormalities. To determine if crude oil and/or dispersant pose a neurological risk, we have initiated investigations to evaluate their effects in a rodent model. Male Sprague-Dawley rats were exposed by whole-body inhalation exposure to the dispersant, COREXIT EC9500A (approximately 27 mg/m3 x 5h/day x 1d), and various indices of neural dysfunction were evaluated in discrete brain areas, at 1 or 7d post-exposure. Exposure to the dispersant did not elicit neuroinflammation or oxidative stress in any of the brain areas examined. However, up-regulation of L-type voltage-gated calcium channel, as well as, altered expression of synaptic and cytoskeletal proteins were observed in the striatum and hippocampus. Whether these molecular aberrations will persist and cause long-term neurological deficits remains to be ascertained.
Crude-oil; Oil-mists; Aerosols; Inhalation-studies; Neurological-reactions; Laboratory-animals; Animal-studies; Animals
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The FASEB Journal
Page last reviewed: March 18, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division